|
|
Is antiretroviral treatment of primary HIV infection clinically justified on the basis of current evidence?
Smith DE, Walker BD, Cooper DA, Rosenberg ES, Kaldor JM.
AIDS
2004 Mar 26;18(5):709-18.
Go to
PubMed entry
|
Reviewed by
Susa Coffey, MD
Comment
Although treatment of primary HIV infection can effectively improve surrogate markers of virologic and immunologic activity, it is not clear that early treatment results in long-term clinical benefit.
This article evaluates the literature on treatment of primary HIV infection and reviews issues of importance on the subject, such as potential advantages and disadvantages of early treatment, effects of short-term treatment, and effects on viral set-point and disease progression. It describes a heterogeneous group of studies that provide suggestive but contradictory results. Unfortunately, none of the studies reported to date has an appropriate design or sufficient power to answer fundamental questions about the treatment of primary HIV. The authors of the article conclude:
"Based on currently published data, there is no clear evidence that patients with access to antiretroviral therapy have any greater clinical benefit if therapy is introduced immediately during or prior to their seroconversion illness."
|
| |
|
Copyright 2010, the AIDS Education & Training Centers National Resource Center, unless otherwise noted. All rights reserved. Email
webmaster@aidsetc.org
with questions, comments, or problems.
See
disclaimer
for usage guidelines.
|
