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The following table summarizes recent additions to the HIV InSite
Database of Antiretroviral Drug Interactions
. For a full description of the updates, including references to the studies from which the data were derived, click on a specific drug name in the table below and search for the interacting agent.
New ARV Interactions (April-July 2009)| Drug One | Drug Two | Clinical Effects | Mechanisms | Management |
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Source: McNicholl I. HIV InSite
Database of Antiretroviral Drug Interactions
. University of California San Francisco: Center for HIV Information; 2009
| | Tenofovir | Etravirine | | | No dosage adjustment necessary | | Nevirapine | Fluconazole | Possibly ↑ nevirapine effects | Inhibition of CYP450 3A4 by fluconazole | No dosage adjustment necessary | | Atazanavir | Simvastatin | ↑ simvastatin effects (eg, myopathy, rhabdomyolysis) | Inhibition of CYP450 3A4 by atazanavir |
Do not coadminister
Alternative agents:
Atorvastatin (low dose); pravastatin
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