As recommendations evolve, patients who have begun highly active
antiretroviral therapy at CD4 T cell counts >350/mm3
may wish to discontinue treatment. There are no clinical data addressing
whether or not this should be done or can be accomplished safely.
Potential benefits include reduction of toxicities, drug-drug interactions,
selection of resistant variants, and improvement in the quality
of life. Potential risks include rebound in viral replication and
renewed immunologic deterioration. If the patient and physician
agree to discontinue therapy the patient should be closely monitored.