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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Multicenter Review of Protease Inhibitors in 89 Pregnancies [Morris AB, et al. JAIDS 2000;25:306]: This is a retrospective survey of six centers in the U.S. in 1997-98 to evaluate PIs for safety in pregnancy. There were 89 women with a perinatal transmission rate of 0. The prematurity rate was 19%, which is comparable to earlier reports of HIV-infected women. The frequency of maternal, obstetrical, and infant events possibly related to PIs was infrequent. The authors concluded that these agents are safe for pregnant women and infants.
Comment: The results of this study are reassuring for those using HAART during pregnancy. The major concern is the adequacy of levels of PIs during pregnancy.
posted 1/4/2001





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