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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Differential Impact of Combined Antiretroviral Therapy on the Survival of Italian Patients with Specific AIDS-Defining Illnesses [Conti S, et al. JAIDS 2001;25:451]: The authors analyzed data for 35,318 persons with HIV infection to determine probability of survival at 24 months after an AIDS-defining diagnosis. The results showed that mortality at 24 months was decreased by 55 - 80% for those diagnosed before 1996 compared to those diagnosed after 1996. The exceptions were primary lymphoma of the brain and Burkitt's lymphoma.
Comment: The authors claim this is the first study to show a differential impact of HAART on survival in patients with specific AIDS-defining conditions. Clinicians who deal with large numbers of HIV-infected patients will not be surprised by the outcome, although these two forms of lymphoma accounted for only 0.9% of all AIDS-defining diagnoses in this cohort. Particularly impressive was the change for PML in which the two-year mortality decreased 65%.
posted 1/18/2001





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