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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Durability of HIV-1 Viral Suppression Over 3.3 Years with Multi-Drug Antiretroviral Therapy in Previously Drug-Naïve Individuals [Phillips AN et al. AIDS 2001;15:2379] This is a report from Frankfurt in which 336 antiretroviral-naïve patients who began triple therapy and achieved virologic control (<50 c/ml within 24 weeks) were assessed for viral rebound during 543 person-years of follow-up. The results showed the risk of viral rebound was 25% at 3.3 years. Of the 61 patients with viral rebound, 47 had treatment interruption due primarily to co-morbidities. Only 14 (5.2%) had viral breakthrough despite persistent HAART within 3.3 years. The authors conclude that effective HAART, once achieved, can be sustained.
posted 1/18/2002





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