home





























 

















 





















hrsa

participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Residual HIV-1 Disease in Seminal Cells of HIV-1-Infected Men on Suppressive HAART: Latency Without On-Going Cellular Infections [Nunnari G et al. AIDS 2002;16:39] The authors studied viral isolates in peripheral blood mononuclear cells and seminal cells in men taking HAART with VL <50 c/ml in plasma. Viral growth was achieved in PBMC from 16 of 28 (57%) and seminal cells from 5 (18%). The isolates from PBMC were positive for HIV-1 2-LTR circular DNA, but this was not detected in the seminal cells. The authors conclude that new infections do not take place in seminal cells under complete viral suppression in vivo suggesting that latent HIV occurs in seminal cells but represents a "compartment-specific reservoir of HIV."
posted 1/18/2002





Copyright © 2001-2002. The National AIDS Education and Training Centers Program on behalf of its AETC National Resource Center. All rights reserved.

Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained in this site because no single reference or service can take the place of medical training, education, and experience. Consumers are cautioned that this site is not intended to provide medical advice about any specific medical condition they may have or treatment they may need, and they are encouraged to call or see their physician or other health care provider promptly with any health related questions they may have.