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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Impact of Discontinuation of Initial Protease Inhibitor Therapy on Further Virological Response in a Cohort of Human Immunodeficiency Virus-Infected Patients [Le Moing V et al. CID 2002;34:239] This is a report from the Antiprotease Cohort Study (APROCO), which is a 47 clinic consortium in France. The purpose was to find the frequency and reason for discontinuing the PI of a PI-based HAART regimen in 1281 patients with a median follow-up of 20 months. During the observation period, 51% discontinued the initial PI; this was due to intolerance in 52%, poor adherence in 22% and virologic failure in 15%. Discontinuation for intolerance was significantly associated with ritonavir treatment, female sex, weight less than 50 kg, and depression.
posted 1/28/2002





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