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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



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Patterns of Resistance Mutations to Antiretroviral Drugs in Extensively Treated HIV-1-Infected Patients with Failure of Highly Active Antiretroviral Therapy [Rousseau M-N, et al. JAIDS 2001;26:36]: This is a report from France concerning 22 patients who had multiple failures with antiretroviral therapy. Genotypic resistance testing showed extensive resistance mutations on both the RT and the P genes. The most common mutations on the RT gene were at codons 215 (100%), 41 (95%), 67 (91%), and 210 (77%). The most extensive mutations on the protease gene were at condons 63 (95%), 10 (86%), 90 (86%), 71 (77%), 46 (50%), 36 (45%), and 84 (45%). RT codon mutations were found in 12 (80%) of the NNRTI-experienced patients. The authors concluded that genotypic resistance tests confirm the lack of alternative salvage regimens in patients with heavy prior exposures to antiretroviral agents.
posted 1/30/2001





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