home





























 

















 





















hrsa

participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Lactacidemia in Asymptomatic HIV-Infected Subjects Receiving Nucleoside Reverse-Transcriptase Inhibitors [Boffito M et al. CID 2002;34:558] The authors measured lactate levels in asymptomatic patients receiving NRTIs for various periods. There were 50 subjects divided into five groups according to duration of therapy, and including one group that was NRTI-naïve. The results are shown in the table below:

 
Mean mM
Range mM
NRTI naïve
1.29
0.58-1.50
NRTI <1 yr
1.95
1.30-3.62
NRTI >5 yrs
1.15
0.71-1.58

Comment: The sample size here may be too small to draw conclusions, but an interesting feature of this analysis is the observation that long-term treatment with NRTIs may be associated with adaptation over time.
posted 2/20/2002





Copyright © 2001-2002. The National AIDS Education and Training Centers Program on behalf of its AETC National Resource Center. All rights reserved.

Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained in this site because no single reference or service can take the place of medical training, education, and experience. Consumers are cautioned that this site is not intended to provide medical advice about any specific medical condition they may have or treatment they may need, and they are encouraged to call or see their physician or other health care provider promptly with any health related questions they may have.