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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Hepatitis C Virus Load Is Associated with Human Immunodeficiency Virus Type 1 Disease Progression In Hemophiliacs [Daar ES et al. JID 2001;183:589]: This report from the Hemophilia Growth and Development Study is a multicenter U.S. study that enrolled 207 HIV-HCV co-infected patients in 1989-90. Participants were evaluated with annual measurements of CD4 cell counts, HIV viral load, and HCV viral load. The results showed that each log increase in the HCV viral load was associated with a relative risk (RR) of 1.7 for clinical progression of HIV and a RR of 1.5 for death.
Comment: HCV and HIV co-infection has been the subject of multiple reports, which have often shown that HCV has little impact on the rate of progression of HIV, but HIV (and alcohol consumption) have an important impact on the rate of liver disease from HCV. Among the best studies are those in patients with hemophilia [Lancet 1999;350:1425]. The present study seems to indicate that the relationship is more complicated than previously thought, although the mechanism is unclear.
posted 3/1/2001





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