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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



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Pulmonary Pathology in Patients with AIDS: An Autopsy Study from Mumbai [Lanjewar DN and Duggal R. HIV Medicine 2001;2:266] This is an autopsy study of 143 patients with HIV infection with a focus on the spectrum of pulmonary lesions. The results showed pulmonary pathology in 126 (88%) including TB in 85 (59%), bacterial pneumonia in 26 (18%), CMV in 10 cases (7%), cryptococcosis in 8 (6%), and P. carinii in 7 (5%).
Comment: The unusual finding in this case series compared with other reports is the paucity of PCP. The potential explanations for the disparate results compared to findings in industrialized countries include: 1) predominance of other pathogens such as tuberculosis, 2) different epidemiology with sparse rates of P. carinii, 3) lack of diagnostic tests to detect PCP, and 4) earlier death at a stage of disease that does not yet predispose to PCP. This study certainly supports the concern for high rates for TB.
posted 3/05/2002





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