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Estimated
Global Distribution and Regional Spread of HIV-1 Genetic Subtypes
in the Year 2000 [Osmanov S et al. JAIDS 2002;29:184]
This is a
report from the Joint HIV Vaccine Initiative of WHO and the Joint
United Nations Program on HIV/AIDS. The purpose of this initiative
was to determine the global distribution and regional spread of
different HIV genetic subtypes for the year 2000 using molecular
virology studies of strains collected in HIV/AIDS surveillance.
Projections for totals were based on estimates of new cases in 2000
using representative samples from various regions. The results with
4,250 strains show that the dominant subtypes for new cases in 2000
were type C-47%, subtype A-27% and subtype B-12%. The following
table shows the distribution of subtypes by region listed in rank
order for the estimates for new infections in 2000.
| Distribution
of HIV-1 Subtypes - 2000 |
| |
|
Subtypes |
| Region |
No.
New
Infections 2000 |
Samples |
A |
B |
C |
D |
E |
F |
| S.
Africa |
1,680,000 |
744 |
1 |
4 |
94 |
0 |
0 |
0 |
| W.
Africa |
850,000 |
1921 |
80 |
1 |
2 |
2 |
0 |
3 |
| E.
Africa |
700,000 |
1969 |
56 |
2 |
7 |
33 |
0 |
0 |
| S.
Asia |
550,000 |
52 |
2 |
2 |
96 |
0 |
0 |
0 |
| Ethiopia |
350,000 |
40 |
0 |
3 |
95 |
3 |
0 |
0 |
| Central
Africa |
260,000 |
536 |
62 |
0 |
5 |
6 |
1 |
6 |
| East
Europe |
250,000 |
536 |
56 |
36 |
4 |
2 |
0 |
0 |
| SE
Asia |
230,000 |
640 |
0 |
32 |
1 |
0 |
63 |
0 |
| Latin
America |
210,000 |
933 |
0 |
81 |
2 |
0 |
0 |
8 |
| E.
Asia |
130,000 |
84 |
5 |
82 |
0 |
1 |
11 |
0 |
| N.
Africa Mideast |
80,000 |
25 |
44 |
40 |
4 |
4 |
0 |
|
| N.
America |
45,000 |
57 |
0 |
96 |
0 |
0 |
0 |
3 |
| W.
Europe |
30,000 |
967 |
7 |
84 |
2 |
1 |
4 |
1 |
| Total |
5,365,000 |
4,250 |
27 |
12 |
47 |
5 |
3 |
1 |
Comment: This
paper is a potentially important contribution in terms of global
efforts in HIV diagnosis, treatment and vaccine development.
posted
3/12/2002
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