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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Prophylaxis with a nevirapine-containing triple regimen after exposure to HIV-1 [Benn PD, et al. Lancet 2001;357:687]: The investigators from London report their experience with nevirapine-containing regimens for prophylaxis after occupational or sexual exposure to HIV by 57 patients. The follow-up showed that five developed grade 3-4 drug-induced hepatitis including two with a rash. The authors conclude that, despite the biological rationale for this regimen, safety issues make it unacceptable where alternative regimens are available.
Comment: There have been substantial reports recently about nevirapine-associated hepatic injury. Thus, this report does not come as a surprise, but simply adds to the weight of prior concerns.
posted 3/20/2001





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