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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Impact of Human Immunodeficiency Virus Infection on Progression to End-Stage Liver Disease in Individuals with Hemophilia and Hepatitis C Virus Infection [Ragni MV and Belle SH. JID 2001;183:1112]: The authors review the natural history of HCV in 157 patients with hemophilia including 85 with HIV co-infection. The average duration of HCV was 24 years. After adjusting for HBVs Ag and history of alcoholism, the relative risk for end-stage liver disease conferred by HIV infection was 3.72.
Comment: Previous authors have pointed out the high risk of HCV/HIV co-infection in persons with hemophilia. Prior studies show that >80% of patients with hemophilia over 18 years of age have HCV infection, 60% have intermittent or persistent elevations of ALT, and 20 - 25% develop biopsy-proven cirrhosis [Lancet 1985;1:495]. About 40% of hemophilia patients have HCV and HIV co-infection. The results of this report suggests that the risk of progression to cirrhosis is magnified by about four-fold in those with HIV co-infection, but the mechanism of this risk is not known.
posted 4/13/2001





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