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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Nevirapine or efavirenz combined with two nucleoside reverse transcriptase inhibitors compared to HAART: A meta-analysis of randomized clinical trials [Torre D, et al. HIV Clin Trials 2001;2:113]: The authors performed a meta-analysis of clinical trials with NVP- or EFV-based triple drug regimens versus PI-based triple drug regimens in five studies with a total of 730 patients. Baseline data showed that 69% were treatment-naïve, the mean CD4 cell count was 345/mm3, and the mean duration of follow-up was 38 weeks. Virologic response was achieved in 215/348 (62%) of patients treated with an NNRTI-based regimen compared to 174/343 (51%) treated with a PI-based regimen. Virologic response was noted in 60% given NVP and 63% of those given EFV. The frequency of adverse events was approximately the same in both groups, but the frequency of rash was significantly greater in those given NNRTIs (11% vs. 4%).
posted 4/25/2001





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