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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



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Duration of ruptured membranes and vertical transmission of HIV-1: A meta-analysis from 15 prospective cohort studies [The International Perinatal HIV Group. AIDS 2001;15:357]: The authors analyzed 4,721 deliveries in 15 prospective cohort studies to determine the association between the duration of ruptured membranes and risk of HIV transmission. The results showed an increased risk of about 2% with each one hour increase in the duration of ruptured membranes. Among patients with AIDS, the probability of perinatal transmission increased from 8% to 31% when the duration of ruptured membranes increased from two hours to 24 hours.
Comment: This is information that has been previously published, but the present study represents the most comprehensive analysis to date.
posted 4/25/2001





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