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hrsa

participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



HIV Lipodystrophy: A Review [Kravcik S. HIV Clin Trials 2000;1:37]: The author reviews lipodystrophy and shows a proposed definition based on a prior report by Carr A, et al. [Lancet 1999;353:2093]:

  1. One or more of the following based on patient report or physical exam:
    1. Fat wasting of arms, legs, face, and/or buttock.
    2. Central obesity involving abdomen, dorsal spine (buffalo hump), and breasts.
  2. One or more of the following metabolic changes:
    1. Fasting triglycerides >174 mg/dL.
    2. Fasting total cholesterol >214 mg/dL.
    3. Fasting C-peptide >7.5 mg/mL.
    4. Glucose intolerance with a fasting glucose of 110 - 126 mg/dL, impaired glucose tolerance at 140 - 240 mg/dL, or diabetes with fasting glucose >126 mg/dL.
  3. No active AIDS-related complication.
  4. No current steroid or immune modulator therapy.
  5. Diagnosis: Standard anthropometric measurements (waste:hip ratio, skinfold thickness, weight and height) or imaging [ultrasound, CT of the abdomen, and VAT:TAT ratio (visceral adipose tissue: total adipose tissue)].
posted 5/3/2001




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