home





























 

















 





















hrsa

participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



NEWS AND NEW DEVELOPMENTS



Update on Drug Resistance Mutations in HIV-1 [D'Aquila RT et al. Topics in HIV Medicine 2001; 9: 31]: The "Resistance Mutations Project Panel" has provided updated recommendations for interpreting resistance tests. Major changes are summarized below:

  • There is no longer a distinction between primary and secondary resistance mutations in the reverse transcriptase gene. The rationale is based on the observation that the sequence of evolution and the contribution to total resistance is debated for these mutations. However, the distinction between primary and secondary mutations will be retained for the protease gene since these correlate with the magnitude of resistance.
  • The nucleotide RT inhibitor, tenofovir, has been added. The resistance gene is K65R.
  • Mutations that confer resistance to lopinavir have been added. These are all secondary mutations and include those at codons 10, 20, 24, 46, 53, 54, 71, 82, 84 and 90.
  • There is now the addition of the "multi-protease inhibitor resistance," in which the primary mutations are at codons 46, 82, 84 and 90.

Additional information is available from http://www.iasusa.org.
posted 6/22/2001





Copyright © 2001-2002. The National AIDS Education and Training Centers Program on behalf of its AETC National Resource Center. All rights reserved.

Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained in this site because no single reference or service can take the place of medical training, education, and experience. Consumers are cautioned that this site is not intended to provide medical advice about any specific medical condition they may have or treatment they may need, and they are encouraged to call or see their physician or other health care provider promptly with any health related questions they may have.