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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



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Pulmonary Infiltrates in HIV-Infected Patients in the Highly Active Antiretroviral Therapy Era in Spain [Benito N et al. JAIDS 2001; 27: 35]: This is a prospective observational study of consecutive hospital admissions for HIV-infected patients in Barcelona for one year beginning April 1998 to March 1999. During this time there were 102 episodes of admissions for patients with pulmonary infiltrates, and these patients underwent a systematic evaluation for etiologic diagnosis. A likely pathogen was found in 62 cases (61%). Bacterial pneumonia accounted for 36 (58%) and S. pneumoniae represented 23. P. carinii accounted for 17 (27%), there were 9 cases of TB (15%), and viruses accounted for 4 (6%). The authors analyzed the distribution of cases among those with HAART and those not receiving this treatment. There were no differences in the rate of bacterial pneumonia or in the rate of mycobacterial infections in these two groups.
Comment: This is the first major study of the etiology of pneumonia in AIDS patients in recent years and it shows high rates of bacterial infection, PCP and TB. Bacterial pathogens are those found in patients without HIV infection. Fifty-eight (62%) of the patients had injection drug use as a risk factor for HIV, which represents an independent risk for bacterial pneumonia.
posted 7/3/2001





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