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participating institutions:
Johns Hopkins University AIDS Service, New York State DOH AIDS Institute, The CORE Center, Cook County Hospital



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Prevalence and Clinical Significance of Splenomegaly in Asymptomatic Human Immunodeficiency Virus Type 1-infected Adults [Furrer H, et al. CID 2000; 30: 943]: This is another report from the Swiss HIV Cohort Study of 70 consecutive patients with asymptomatic HIV infection. Splenomegaly was found by physical exam in 23% and by ultrasound (over 120 mm in long axis) in 66%. During a one-year follow-up, there was no evidence of disease or complications associated with splenomegaly.
Comment: There are two practical applications of these data: first, splenomegaly is relatively common in patients with asymptomatic HIV disease and generally does not indicate an important complication such as lymphoma. The second application is that patients with unexplained splenomegaly should have consideration of HIV as a possible diagnosis. posted 8/11/2000







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