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HIV-Associated
Hematologic Disorders are Correlated With Plasma Viral Load and
Improve Under Highly Active Antiretroviral Therapy [Servais
J et al. JAIDS 2001;28:221] This a two-phase study from Luxembourg
to determine the relationship between viral load and marrow suppression,
and response of suppression to HAART. The initial phase of this
study showed a significant inverse correlation between the HIV plasma
viral load and all three hematologic parameters in a sample size
of 207. These reduced levels correlated with CD4 cell count. The
second phase of this study concerned the response of patients with
hematologic alterations before and after HAART. The results showed
hematologic reconstitution for all three cell lines, which became
statistically significant after 6 months. The results are shown
in the following table:
| Parameter
|
No. |
Baseline
(Mean) |
Response
(Mean) |
| Platelets
<150,000/mm3 |
27 |
110,000/mm3 |
180,000/mm3 |
| Hemoglobin
<12 g/dL |
24 |
10.7
gm/dL |
12.3g/dL |
| Absolute
neutrophil count <2000/dL |
36 |
1,260/dL |
2,240/dL |
Comment:
Many studies have shown that HIV infection is often complicated
by marrow suppression which usually occurs in advanced disease,
although thrombocytopenia alone is often seen relatively early in
the course. The study here shows a good correlation between viral
load and marrow suggesting a direct effect of HIV. This study also
shows that HAART is associated with significant increases in all
three cell lines.
posted
11/19/2001
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